PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R).

ABSTRACT: While neuroinflammation is an evolving concept and the cells involved and their functions are being defined, microglia are understood to be a key cellular mediator of brain injury and repair. The ability to measure microglial activity specifically and noninvasively would be a boon to the study of neuroinflammation, which is involved in a wide variety of neuropsychiatric disorders including traumatic brain injury, demyelinating disease, Alzheimer's disease (AD), and Parkinson's disease, among others. We have developed [¹¹C]CPPC [5-cyano-N-(4-(4-[¹¹C]methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide], a positron-emitting, high-affinity ligand that is specific for the macrophage colony-stimulating factor 1 receptor (CSF1R), the expression of which

SUBMITTER: Horti AG 

PROVIDER: S-EPMC6358677 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature