Niche adaptation limits bacteriophage predation of Vibrio cholerae in a nutrient-poor aquatic environment.

ABSTRACT: Vibrio cholerae, the causative agent of cholera, has reservoirs in fresh and brackish water where it interacts with virulent bacteriophages. Phages are the most abundant biological entity on earth and coevolve with bacteria. It was reported that concentrations of phage and V. cholerae inversely correlate in aquatic reservoirs and in the human small intestine, and therefore that phages may quench cholera outbreaks. Although there is strong evidence for phage predation in cholera patients, evidence is lacking for phage predation of V. cholerae in aquatic environments. Here, we used three virulent phages, ICP1, ICP2, and ICP3, commonly shed by cholera patients in Bangladesh, as models to understand the predation dynamics in microcosms simulating aquatic environments. None

SUBMITTER: Silva-Valenzuela CA 

PROVIDER: S-EPMC6358685 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature