Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors.

ABSTRACT: Major depressive disorder (MDD) is a devastating disease that arises in a background of environmental risk factors, such as chronic stress, that produce reactive oxygen species (ROS) in the brain. The chronic stress-induced ROS production involves Ca²⁺ signals; however, the mechanism is poorly understood. Transient receptor potential melastatin type 2 (TRPM2) is a Ca²⁺-permeable cation channel that is highly expressed in the brain. Here we show that in animal models of chronic unpredictable stress (CUS), deletion of TRPM2 (Trpm2^-/- ) produces antidepressant-like behaviors in mice. This phenotype correlates with reduced ROS, ROS-induced calpain activation, and enhanced phosphorylation of two Cdk5 targets including synapsin 1 and histone deacety

SUBMITTER: Ko SY 

PROVIDER: S-EPMC6358711 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature