Mechanistic Computational Models of MicroRNA-Mediated Signaling Networks in Human Diseases.

ABSTRACT: MicroRNAs (miRs) are endogenous non-coding RNA molecules that play important roles in human health and disease by regulating gene expression and cellular processes. In recent years, with the increasing scientific knowledge and new discovery of miRs and their gene targets, as well as the plentiful experimental evidence that shows dysregulation of miRs in a wide variety of human diseases, the computational modeling approach has emerged as an effective tool to help researchers identify novel functional associations between differential miR expression and diseases, dissect the phenotypic expression patterns of miRs in gene regulatory networks, and elucidate the critical roles of miRs in the modulation of disease pathways from mechanistic and quantitative perspectives. Here we will review the r

SUBMITTER: Zhao C 

PROVIDER: S-EPMC6358731 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature