Delineating the Dynamic Transcriptome Response of mRNA and microRNA during Zebrafish Heart Regeneration.

ABSTRACT: Heart diseases are the leading cause of death for the vast majority of people around the world, which is often due to the limited capability of human cardiac regeneration. In contrast, zebrafish have the capacity to fully regenerate their hearts after cardiac injury. Understanding and activating these mechanisms would improve health in patients suffering from long-term consequences of ischemia. Therefore, we monitored the dynamic transcriptome response of both mRNA and microRNA in zebrafish at 1⁻160 days post cryoinjury (dpi). Using a control model of sham-operated and healthy fish, we extracted the regeneration specific response and further delineated the spatio-temporal organization of regeneration processes such as cell cycle and heart function. In addition, we identified novel (miR-148

SUBMITTER: Klett H 

PROVIDER: S-EPMC6359357 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature