Novel Formulations of C-Peptide with Long-Acting Therapeutic Potential for Treatment of Diabetic Complications.

ABSTRACT: The development and application of novel nanospheres based on cationic and anionic random amphiphilic polypeptides with prolonged stability were proposed. The random copolymers, e.g., poly(l-lysine-co-d-phenylalanine) (P(Lys-co-dPhe)) and poly(l-glutamic acid-co-d-phenylalanine) (P(Glu-co-dPhe)), with different amount of hydrophilic and hydrophobic monomers were synthesized. The polypeptides obtained were able to self-assemble into nanospheres. Such characteristics as size, PDI and ζ-potential of the nanospheres were determined, as well as their dependence on pH was also studied. Additionally, the investigation of their biodegradability and cytotoxicity was performed. The prolonged stability of nanospheres was achieved via introduction of d-amino acids into the

SUBMITTER: Zashikhina N 

PROVIDER: S-EPMC6359607 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature