Vectors for Glioblastoma Gene Therapy: Viral & Non-Viral Delivery Strategies.

ABSTRACT: Glioblastoma multiforme is the most common and aggressive primary brain tumor. Even with aggressive treatment including surgical resection, radiation, and chemotherapy, patient outcomes remain poor, with five-year survival rates at only 10%. Barriers to treatment include inefficient drug delivery across the blood brain barrier and development of drug resistance. Because gliomas occur due to sequential acquisition of genetic alterations, gene therapy represents a promising alternative to overcome limitations of conventional therapy. Gene or nucleic acid carriers must be used to deliver these therapies successfully into tumor tissue and have been extensively studied. Viral vectors have been evaluated in clinical trials for glioblastoma gene therapy but have not achieved FDA approval due to i

SUBMITTER: Caffery B 

PROVIDER: S-EPMC6359729 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature