Economic impact of potentially inappropriate prescribing and related adverse events in older people: a cost-utility analysis using Markov models.

ABSTRACT:

Objectives

To determine the economic impact of three drugs commonly involved in potentially inappropriate prescribing (PIP) in adults aged ≥65 years, including their adverse effects (AEs): long-term use of non-steroidal anti-inflammatory drugs (NSAIDs), benzodiazepines and proton pump inhibitors (PPIs) at maximal dose; to assess cost-effectiveness of potential interventions to reduce PIP of each drug.

Design

Cost-utility analysis. We developed Markov models incorporating the AEs of each PIP, populated with published estimates of probabilities, health system costs (in 2014 euro) and utilities.

Participants

A hypothetical cohort of 65 year olds analysed over 35 1-year cycles with discounting at 5% per year.

Outcome measures

Incremental cost, quality-adjusted life

SUBMITTER: Moriarty F 

PROVIDER: S-EPMC6359741 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature