Prevalence of germline mutations in the TP53 gene in patients with early-onset breast cancer in the Mexican population.

ABSTRACT:

Background

Heterozygous germline TP53 gene mutations result in Li-Fraumeni Syndrome (LFS). Breast cancer (BC) is the most frequent tumor in young women with LFS. An important issue related to BC in the Mexican population is the average age at diagnosis, which is approximately 11 years younger than that of patients in the United States (U.S.) and Europe. The aim of this study was to determine the prevalence of germline mutations in TP53 among young Mexican BC patients.

Methods

We searched for germline mutations in the TP53 gene using targeted next-generation sequencing (NGS) in 78 BC patients younger than 45 years old (yo) who tested negative for BRCA1/2 mutations. A group of 509 Mexican women aged 45yo or older without personal or family BC history (parents/grandparents) was

SUBMITTER: Gallardo-Alvarado LN 

PROVIDER: S-EPMC6359755 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature