ATM rs189037 (G > A) polymorphism increased the risk of cancer: an updated meta-analysis.

ABSTRACT: BACKGROUND:Rs189037 (G > A) is a functional single nucleotide polymorphism (SNP) in the Ataxia-telangiectasia mutated (ATM) gene that may be associated with the risk of cancer. We performed a meta-analysis to determine whether rs189037 polymorphism influences the occurrence of cancer and examined the relationship between this SNP and the etiology of cancer. METHODS:Case-control studies were retrieved from literature databases in accordance with established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between rs189037 and cancer. Subgroup analysis and sensitivity analysis also were performed. RESULTS:After inclusion criteria were met, fifteen studies-comprising 8660 patients with cancer (cases) and 9259

SUBMITTER: Zhao ZL 

PROVIDER: S-EPMC6359756 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature