Polygenic risk score increases schizophrenia liability through cognition-relevant pathways.

ABSTRACT: Cognitive deficit is thought to represent, at least in part, genetic mechanisms of risk for schizophrenia, with recent evidence from statistical modelling of twin data suggesting direct causality from the former to the latter. However, earlier evidence was based on inferences from twin not molecular genetic data and it is unclear how much genetic influence 'passes through' cognition on the way to diagnosis. Thus, we included direct measurements of genetic risk (e.g. schizophrenia polygenic risk scores) in causation models to assess the extent to which cognitive deficit mediates some of the effect of polygenic risk scores on the disorder. Causal models of family data tested relationships among key variables and allowed parsing of genetic variance components. Polygenic risk scores were calcu

SUBMITTER: Toulopoulou T 

PROVIDER: S-EPMC6359897 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature