Modulation of Mutant Kras^G12D -Driven Lung Tumorigenesis In Vivo by Gain or Loss of PCDH7 Function.

ABSTRACT: PROTOCADHERIN 7 (PCDH7), a transmembrane receptor and member of the Cadherin superfamily, is frequently overexpressed in lung adenocarcinoma and is associated with poor clinical outcome. Although PCDH7 was recently shown to promote transformation and facilitate brain metastasis in lung and breast cancers, decreased PCDH7 expression has also been documented in colorectal, gastric, and invasive bladder cancers. These data suggest context-dependent functions for PCDH7 in distinct tumor types. Given that PCDH7 is a potentially targetable molecule on the surface of cancer cells, further investigation of its role in tumorigenesis in vivo is needed to evaluate the therapeutic potential of its inhibition. Here, we report the analysis of novel PCDH7 gain- and loss-of-function mouse models an

SUBMITTER: Zhou X 

PROVIDER: S-EPMC6359939 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature