Genetic and Epigenetic Determinants of Aggressiveness in Cribriform Carcinoma of the Prostate.

ABSTRACT: Among prostate cancers containing Gleason pattern 4, cribriform morphology is associated with unfavorable clinicopathologic factors, but its genetic features and association with long-term outcomes are incompletely understood. In this study, genetic, transcriptional, and epigenetic features of invasive cribriform carcinoma (ICC) tumors were compared with non-cribriform Gleason 4 (NC4) in The Cancer Genome Atlas (TCGA) cohort. ICC (n = 164) had distinctive molecular features when compared with NC4 (n = 102). These include: (i) increased somatic copy number variations (SCNV), specifically deletions at 6q, 8p and 10q, which encompassed PTEN and MAP3K7 losses and gains at 3q; (ii) increased SPOP ^mut and ATM^mut ; (iii) enrichment f

SUBMITTER: Elfandy H 

PROVIDER: S-EPMC6359952 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature