Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma.

ABSTRACT:

Purpose

To investigate genomic differences between urothelial carcinomas of the upper tract (UTUC) and bladder (UCB), with a focus on defining the clonal relatedness of temporally distinct tumors.

Experimental design

We prospectively sequenced tumors and matched germline DNA using targeted next-generation sequencing methods. The cohort included 195 UTUC patients and 454 UCB patients. For a subgroup of 29 patients with UTUC and a history of a subsequent UCB, both tumors were analyzed to assess their clonal relatedness.

Results

With the progression to higher UTUC clinical state, there were fewer alterations in the RTK/RAS pathway but more alterations in TP53/MDM2. Compared with UCB, TP53, RB1, and ERBB2 were less frequently altered in UTUC (26% vs. 46%, 3%

SUBMITTER: Audenet F 

PROVIDER: S-EPMC6359971 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature