AXL Is a Putative Tumor Suppressor and Dormancy Regulator in Prostate Cancer.

ABSTRACT: Prostate cancer bone metastasis remains lethal and incurable, and often arises years after elimination of the primary tumor. It is unclear what underlies the decades-long clinical latency before recurrence, but evidence points to the existence of dormant residual tumor cells that disseminated before the primary tumor was eliminated. To design therapies to prevent progression of disseminated tumor cells (DTC) into lethal metastases, it is crucial to understand the mechanism(s) underlying this dormancy. The current study functionally validated our previous observation that implicated the GAS6/AXL axis in mediating DTC dormancy in the bone marrow. AXL-null and AXL-overexpressing prostate cancer cell lines were generated to determine if AXL was necessary and/or sufficient for dormancy.

SUBMITTER: Axelrod HD 

PROVIDER: S-EPMC6359976 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature