α_vβ₃ Integrin Mediates Radioresistance of Prostate Cancer Cells through Regulation of Survivin.

ABSTRACT: The α_vβ₃ integrin is involved in various physiologic and pathologic processes such as wound healing, angiogenesis, tumor growth, and metastasis. The impact of α_vβ₃ integrin on the radiosensitivity of prostate cancer cells and the molecular mechanism controlling cell survival in response to ionizing radiation (IR) was investigated. Both LNCaP cells stably transfected with α_vβ₃ integrin and PC-3 cells that contain endogenous β₃ integrin were used. This study demonstrated that α_vβ₃ integrin increases survival of α_vβ₃-LNCaP cells upon IR while small hairpin RNA (shRNA)-mediated knockdown of α_vβ₃ integrin in PC-3 cells sensitizes to radiation. Expression

SUBMITTER: Wang T 

PROVIDER: S-EPMC6359981 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature