Neurocognitive profiles in the prodrome to psychosis in NAPLS-1.

ABSTRACT:

Background

Most studies of neurocognitive functioning in Clinical High Risk (CHR) cohorts have examined group averages, likely concealing heterogeneous subgroups. We aimed to identify neurocognitive subgroups and to explore associated outcomes.

Methods

Data were acquired from 324 participants (mean age 18.4) in the first phase of the North American Prodrome Longitudinal Study (NAPLS-1), a multi-site consortium following individuals for up to 2 1/2 years. We applied Ward's method for hierarchical clustering data to 8 baseline neurocognitive measures, in 166 CHR individuals, 49 non-CHR youth with a family history of psychosis, and 109 healthy controls. We tested whether cluster membership was associated with conversion to psychosis, social and role functioning, and follow-up d

SUBMITTER: Velthorst E 

PROVIDER: S-EPMC6359987 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature