Prolactin-Induced Protein is a novel biomarker for Keratoconus.

ABSTRACT:

Purpose

The purpose of the study was to investigate the role of Prolactin-Induced Protein (PIP) as a predictive biomarker for Keratoconus (KC).

Participants

This study included one hundred and forty-seven patients with KC (105 male, 42 female), and sixty healthy controls (27 male, 33 female).

Methods

Tears, plasma and saliva samples were collected from all participants. In both KC and healthy groups all collected samples were divided into four age subgroups (15-24y), (25-34y), (35-44y) and (45y and up). Samples were analyzed using western blot (WB) and enzyme-linked immunosorbent assay (ELISA). Areas under the receiver operating characteristic curves (AUROCs) were used to evaluate diagnostic accuracy for distinguishing between KC and healthy eyes.

Main outcome meas

SUBMITTER: Sharif R 

PROVIDER: S-EPMC6360109 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature