Parametric estimation of association in bivariate failure-time data subject to competing risks: sensitivity to underlying assumptions.

ABSTRACT: There has arisen a considerable body of research addressing the estimation of association between paired failure times in the presence of competing risks. In a 2002 paper, Bandeen-Roche and Liang proposed the conditional cause-specific hazard ratio (CCSHR) as a measure of this association and a parametric method by which to estimate it. The method features an interpretable decomposition of the CCSHR into factors describing the association between a pair's times to first failure among multiple failure causes and the association in pair members' propensities to fail due to a common cause. There were indications of sensitivity to model assumptions, however, in the 2002 work. Here we report a detailed study of the method's sensitivity to its parametric assumptions. We conclude that the method'

SUBMITTER: Kim J 

PROVIDER: S-EPMC6360142 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature