Expression and Activation of BK_Ca Channels in Mice Protects Against Ischemia-Reperfusion Injury of Isolated Hearts by Modulating Mitochondrial Function.

ABSTRACT: Aims: Activation and expression of large conductance calcium and voltage-activated potassium channel (BK_Ca) by pharmacological agents have been implicated in cardioprotection from ischemia-reperfusion (IR) injury possibly by regulating mitochondrial function. Given the non-specific effects of pharmacological agents, it is not clear whether activation of BK_Ca is critical to cardioprotection. In this study, we aimed to decipher the mechanistic role of BK_Ca in cardioprotection from IR injury by genetically activating BK_Ca channels. Methods and Results: Hearts from adult (3 months old) wild-type mice (C57/BL6) and mice expressing genetically activated BK_Ca (Tg-BK_Ca ^R207Q, referred as Tg-BK_Ca)

SUBMITTER: Goswami SK 

PROVIDER: S-EPMC6360169 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature