Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.

ABSTRACT: Recurrent mutational activation of the MAP kinase pathway in plasma cell myeloma implicates growth factor-like signaling responses in the biology of Ab-secreting cells (ASCs). Physiological ASCs survive in niche microenvironments, but how niche signals are propagated and integrated is poorly understood. In this study, we dissect such a response in human ASCs using an in vitro model. Applying time course expression data and parsimonious gene correlation network analysis (PGCNA), a new approach established by our group, we map expression changes that occur during the maturation of proliferating plasmablast to quiescent plasma cell under survival conditions including the potential niche signal TGF-β3. This analysis demonstrates a convergent pattern of differentiation, linking unfolded protein

SUBMITTER: Stephenson S 

PROVIDER: S-EPMC6360259 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature