Causal effects of blood lipids on amyotrophic lateral sclerosis: a Mendelian randomization study.

ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disorder that is predicted to increase across the globe by ~70% in the following decades. Understanding the disease causal mechanism underlying ALS and identifying modifiable risks factors for ALS hold the key for the development of effective preventative and treatment strategies. Here, we investigate the causal effects of four blood lipid traits that include high-density lipoprotein, low-density lipoprotein (LDL), total cholesterol and triglycerides on the risk of ALS. By leveraging instrument variables from multiple large-scale genome-wide association studies in both European and East Asian populations, we carry out one of the largest and most comprehensive Mendelian randomization analyses performed to date on th

SUBMITTER: Zeng P 

PROVIDER: S-EPMC6360326 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature