Immunobiochemical Reconstruction of Influenza Lung Infection-Melanoma Skin Cancer Interactions.

ABSTRACT: It was recently reported that acute influenza infection of the lung promoted distal melanoma growth in the dermis of mice. Melanoma-specific CD8+ T cells were shunted to the lung in the presence of the infection, where they expressed high levels of inflammation-induced cell-activation blocker PD-1, and became incapable of migrating back to the tumor site. At the same time, co-infection virus-specific CD8+ T cells remained functional while the infection was cleared. It was also unexpectedly found that PD-1 blockade immunotherapy reversed this effect. Here, we proceed to ground the experimental observations in a mechanistic immunobiochemical model that incorporates T cell pathways that control PD-1 expression. A core component of our model is a kinetic motif, which we call a PD-1 Double Inco

SUBMITTER: Nikolaev EV 

PROVIDER: S-EPMC6360404 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature