Serum Proteomic Study of Women With Obsessive-Compulsive Disorder, Washing Subtype.

ABSTRACT:

Introduction

Many genetic studies are conducted on Obsessive-Compulsive Disorder (OCD). however, a high-throughput examination of proteome profile of this severe disease has not been performed yet.

Methods

Here, the proteomic study of OCD patients' serum samples was conducted by the application of Two-Dimensional Electrophoresis (2DE) followed by Mass Spectrometry (MALDI-TOF-TOF).

Results

A total of 240 protein spots were detected and among them, five significant differentially expressed protein spots with the fold change of ≥1.5 were considered for further evaluations. These proteins include IGKC, GC, HPX, and two isoforms of HP. While IGKC and HP show down-regulation, GC and HPX indicate up-regulation. Moreover, a validation study of overall HP levels in patients' s

SUBMITTER: Zamanian-Azodi M 

PROVIDER: S-EPMC6360490 | biostudies-literature | 2018 Sep-Oct

REPOSITORIES: biostudies-literature