Gene2vec: distributed representation of genes based on co-expression.

ABSTRACT:

Background

Existing functional description of genes are categorical, discrete, and mostly through manual process. In this work, we explore the idea of gene embedding, distributed representation of genes, in the spirit of word embedding.

Results

From a pure data-driven fashion, we trained a 200-dimension vector representation of all human genes, using gene co-expression patterns in 984 data sets from the GEO databases. These vectors capture functional relatedness of genes in terms of recovering known pathways - the average inner product (similarity) of genes within a pathway is 1.52X greater than that of random genes. Using t-SNE, we produced a gene co-expression map that shows local concentrations of tissue specific genes. We also illustrated the usefulness of the embedded g

SUBMITTER: Du J 

PROVIDER: S-EPMC6360648 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature