Complex structural rearrangements are present in high-grade dysplastic Barrett's oesophagus samples.

ABSTRACT:

Background

Oesophageal adenocarcinoma (EAC) incidence is increasing and has a poor survival rate. Barrett's oesophagus (BE) is a precursor condition that is associated with EAC and often occurs in conjunction with chronic gastro-oesophageal reflux, however many individuals diagnosed with BE never progress to cancer. An understanding of the genomic features of BE and EAC may help with the early identification of at-risk individuals.

Methods

In this study, we assessed the genomic features of 16 BE samples using whole-genome sequencing. These included non-dysplastic samples collected at two time-points from two BE patients who had not progressed to EAC over several years. Seven other non-dysplastic samples and five dysplastic BE samples with high-grade dysplasia were also exami

SUBMITTER: Newell F 

PROVIDER: S-EPMC6360790 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature