An AR-ERG transcriptional signature defined by long-range chromatin interactomes in prostate cancer cells.

ABSTRACT: The aberrant activities of transcription factors such as the androgen receptor (AR) underpin prostate cancer development. While the AR cis-regulation has been extensively studied in prostate cancer, information pertaining to the spatial architecture of the AR transcriptional circuitry remains limited. In this paper, we propose a novel framework to profile long-range chromatin interactions associated with AR and its collaborative transcription factor, erythroblast transformation-specific related gene (ERG), using chromatin interaction analysis by paired-end tag (ChIA-PET). We identified ERG-associated long-range chromatin interactions as a cooperative component in the AR-associated chromatin interactome, acting in concert to achieve coordinated regulation of a subset of AR target gen

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC6360806 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature