Toward Electrophysiology-Based Intelligent Adaptive Deep Brain Stimulation for Movement Disorders.

ABSTRACT: Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high-frequency stimulation can mimic the effects of ablative neurosurgery in Parkinson's disease (PD), while offering two key advantages to previous procedures: adjustability and reversibility. Deep brain stimulation is now an established therapeutic approach that robustly alleviates symptoms in patients with movement disorders, such as Parkinson's disease, essential tremor, and dystonia, who present with inadequate or adverse responses to medication. Currently, stimulation electrodes are implanted in specific target regions of the basal ganglia-thalamic circuit and stimulation pulses are delivered chronically. To achiev

SUBMITTER: Neumann WJ 

PROVIDER: S-EPMC6361070 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature