Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases.

ABSTRACT: Members of the Flaviviridae family constitute a severe risk to human health. Whilst effective drugs have been developed against the hepacivirus HCV, no antiviral therapy is currently available for any other viruses, including the flaviviruses dengue (DENV), West Nile and Zika viruses. The RNA-dependent RNA polymerase (RdRp) is responsible for viral replication and represents an excellent therapeutic target with no homologue found in mammals. The identification of compounds targeting the RdRp of other flaviviruses is an active area of research. One of the main factors hampering further developments in the field is the difficulty in obtaining high-quality crystal information that could aid a structure-based drug discovery approach. To address this, we have developed a co

SUBMITTER: Riccio F 

PROVIDER: S-EPMC6361211 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature