SMSSVD: SubMatrix Selection Singular Value Decomposition.

ABSTRACT:

Motivation

High throughput biomedical measurements normally capture multiple overlaid biologically relevant signals and often also signals representing different types of technical artefacts like e.g. batch effects. Signal identification and decomposition are accordingly main objectives in statistical biomedical modeling and data analysis. Existing methods, aimed at signal reconstruction and deconvolution, in general, are either supervised, contain parameters that need to be estimated or present other types of ad hoc features. We here introduce SubMatrix Selection Singular Value Decomposition (SMSSVD), a parameter-free unsupervised signal decomposition and dimension reduction method, designed to reduce noise, adaptively for each low-rank-signal in a given data matrix, and represent

SUBMITTER: Henningsson R 

PROVIDER: S-EPMC6361234 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature