Pemetrexed-loaded nanoparticles targeted to malignant pleural mesothelioma cells: an in vitro study.

ABSTRACT:

Purpose

Malignant pleural mesothelioma (MPM) is an aggressive tumor characterized by poor prognosis. Its incidence is steadily increasing due to widespread asbestos exposure. There is still no effective therapy for MPM. Pemetrexed (Pe) is one of the few chemotherapeutic agents approved for advanced-stage disease, although the objective response to the drug is limited. The use of gold nanoparticles (GNPs) as a drug delivery system promises several advantages, including specific targeting of malignant cells, with increased intracellular drug accumulation and reduced systemic toxicity, and, in the case of MPM, direct treatment administration into the pleural space. This study aims at exploring CD146 as a potential MPM cell-specific target for engineered Pe-loaded GNPs and to assess th

SUBMITTER: Cova E 

PROVIDER: S-EPMC6361319 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature