Unravelling the interaction between the DRD2 and DRD4 genes, personality traits and concussion risk.

ABSTRACT:

Background

Concussion occurs when biomechanical forces transmitted to the head result in neurological deficits. Personality may affect the balance between safe and dangerous play potentially influencing concussion risk. Dopamine receptor D2 (DRD2) and dopamine receptor D4 (DRD4) genetic polymorphisms were previously associated with personality traits.

Objectives

This case-control genetic association study investigated the associations of (1) DRD2 and DRD4 genotypes with concussion susceptibility and personality, (2) personality with concussion susceptibility and (3) the statistical model of genotype, personality and concussion susceptibility.

Methods

In total, 138 non-concussed controls and 163 previously concussed cases were recruited from

SUBMITTER: Abrahams S 

PROVIDER: S-EPMC6361366 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature