Therapeutic hypothermia after paediatric cardiac arrest: Pooled randomized controlled trials.

ABSTRACT:

Background

Separate trials to evaluate therapeutic hypothermia after paediatric cardiac arrest for out-of-hospital and in-hospital settings reported no statistically significant differences in survival with favourable neurobehavioral outcome or safety compared to therapeutic normothermia. However, larger sample sizes might detect smaller clinical effects. Our aim was to pool data from identically conducted trials to approximately double the sample size of the individual trials yielding greater statistical power to compare outcomes.

Methods

Combine individual patient data from two clinical trials set in forty-one paediatric intensive care units in USA, Canada and UK. Children aged at least 48 h up to 18 years old, who remained comatose after resuscitation, were randomized wit

SUBMITTER: Scholefield BR 

PROVIDER: S-EPMC6361524 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature