Blood, sweat, and tears: Red Blood Cell-Omics study objectives, design, and recruitment activities.

ABSTRACT:

Background

The Red Blood Cell (RBC)-Omics study was initiated to build a large data set containing behavioral, genetic, and biochemical characteristics of blood donors with linkage to outcomes of the patients transfused with their donated RBCs.

Study design and methods

The cohort was recruited from four US blood centers. Demographic and donation data were obtained from center records. A questionnaire to assess pica, restless leg syndrome, iron supplementation, hormone use, and menstrual and pregnancy history was completed at enrollment. Blood was obtained for a complete blood count, DNA, and ferritin testing. A leukocyte-reduced RBC sample was transferred to a custom storage bag for hemolysis testing at Storage Days 39 to 42. A subset was recalled to evaluate the kinetics an

SUBMITTER: Endres-Dighe SM 

PROVIDER: S-EPMC6361628 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature