Region-Specific Differences in Morphometric Features and Synaptic Colocalization of Astrocytes During Development.

ABSTRACT: It is well established that astrocytes play pivotal roles in neuronal synapse formation and maturation as well as in the modulation of synaptic transmission. Despite their general importance for brain function, relatively little is known about the maturation of astrocytes during normal postnatal development, especially during adolescence, and how that maturation may influence astroglial-synaptic contact. The medial prefrontal cortex (mPFC) and dorsal hippocampus (dHipp) are critical for executive function, memory, and their effective integration. Further, both regions undergo significant functional changes during adolescence and early adulthood that are believed to mediate these functions. However, it is unclear the extent to which astrocytes change during these late developmental periods,

SUBMITTER: Testen A 

PROVIDER: S-EPMC6361709 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature