Persistent Homology for the Quantitative Evaluation of Architectural Features in Prostate Cancer Histology.

ABSTRACT: The current system for evaluating prostate cancer architecture is the Gleason grading system which divides the morphology of cancer into five distinct architectural patterns, labeled 1 to 5 in increasing levels of cancer aggressiveness, and generates a score by summing the labels of the two most dominant patterns. The Gleason score is currently the most powerful prognostic predictor of patient outcomes; however, it suffers from problems in reproducibility and consistency due to the high intra-observer and inter-observer variability amongst pathologists. In addition, the Gleason system lacks the granularity to address potentially prognostic architectural features beyond Gleason patterns. We evaluate prostate cancer for architectural subtypes using techniques from topological data analysis a

SUBMITTER: Lawson P 

PROVIDER: S-EPMC6361896 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature