Dietary Niacin Intake Predicts the Decrease of Liver Fat Content During a Lifestyle Intervention.

ABSTRACT: Niacin inhibits fatty acid flux from adipose tissue to liver, reduces hepatic triglyceride synthesis and increases hepatic lipid oxidation. Thus, niacin may have a role in the regulation of liver fat content in humans. We tested if dietary intake of niacin predicts change of liver fat content during a lifestyle intervention. To this end, we estimated the composition of diet from diaries of 202 healthy subjects at risk of type 2 diabetes undergoing lifestyle intervention comprising physical activity and diet counselling. Total-, subcutaneous- and visceral adipose tissue mass were measured by magnetic resonance (MR) tomography and liver fat content by ¹H-MR spectroscopy at baseline and after 9 months of follow-up. Among fat compartments, liver fat content showed the largest decrea

SUBMITTER: Linder K 

PROVIDER: S-EPMC6362104 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature