Prefrontal networks dynamically related to recovery from major depressive disorder: a longitudinal pharmacological fMRI study.

ABSTRACT: Due to lacking predictors of depression recovery, successful treatment of major depressive disorder (MDD) is frequently only achieved after therapeutic optimization leading to a prolonged suffering of patients. This study aimed to determine neural prognostic predictors identifying non-remitters prior or early after treatment initiation. Moreover, it intended to detect time-sensitive neural mediators indicating depression recovery. This longitudinal, interventional, single-arm, open-label, phase IV, pharmacological functional magnetic resonance imaging (fMRI) study comprised four scans at important stages prior (day 0) and after escitalopram treatment initiation (day 1, 28, and 56). Totally, 22 treatment-free MDD patients (age mean ± SD: 31.5 ± 7.7; females: 50%) suffering from a concurrent

SUBMITTER: Meyer BM 

PROVIDER: S-EPMC6362173 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature