Effects of familial risk and stimulant drug use on the anticipation of monetary reward: an fMRI study.

ABSTRACT: The association between stimulant drug use and aberrant reward processing is well-documented in the literature, but the nature of these abnormalities remains elusive. The present study aims to disentangle the separate and interacting effects of stimulant drug use and pre-existing familial risk on abnormal reward processing associated with stimulant drug addiction. We used the Monetary Incentive Delay task, a well-validated measure of reward processing, during fMRI scanning in four distinct groups: individuals with familial risk who were either stimulant drug-dependent (N = 41) or had never used stimulant drugs (N = 46); and individuals without familial risk who were either using stimulant drugs (N = 25) or not (N = 48). We first examined task-related whole-brain activation followed by a ps

SUBMITTER: Just AL 

PROVIDER: S-EPMC6362203 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature