An Implantable Ultrasonically-Powered Micro-Light-Source (µLight) for Photodynamic Therapy.

ABSTRACT: Photodynamic therapy (PDT) is a promising cancer treatment modality that can selectively target unresectable tumors through optical activation of cytotoxic agents, thus reducing many side effects associated with systemic administration of chemotherapeutic drugs. However, limited light penetration into most biological tissues have so far prevented its widespread adoption beyond dermatology and a few other oncological applications in which a fiber optic can be threaded to the desired locations via an endoscopic approach (e.g., bladder). In this paper, we introduce an ultrasonically powered implantable microlight source, μLight, which enables in-situ localized light delivery to deep-seated solid tumors. Ultrasonic powering allows for small receiver form factor (mm-scale) and power transfer de

SUBMITTER: Kim A 

PROVIDER: S-EPMC6362227 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature