Dendritic Cell Targeting Using a DNA Vaccine Induces Specific Antibodies and CD4⁺ T Cells to the Dengue Virus Envelope Protein Domain III.

ABSTRACT: Dengue fever has become a global threat, causing millions of infections every year. An effective vaccine against all four serotypes of dengue virus (DENV) has not been developed yet. Among the different vaccination strategies available today, DNA vaccines are safe and practical, but currently induce relatively weak immune responses in humans. In order to improve immunogenicity, antigens may be targeted to dendritic cells (DCs), the main antigen presenting cells and orchestrators of the adaptive immune response, inducing T and B cell activation. It was previously shown that a DNA vaccine encoding a fusion protein comprised of an antigen and a single-chain Fv antibody (scFv) specific for the DC endocytic receptor DEC205 induced strong immune responses to the targeted antigen. In this work, w

SUBMITTER: Zaneti AB 

PROVIDER: S-EPMC6362411 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature