Light Control of Protein Solubility Through Isoelectric Point Modulation.

ABSTRACT: We previously described the photoactivated depot or PAD approach that allows for the light control of therapeutic protein release. This approach relies on the ability to use light to change a protein's solubility. Traditionally this was accomplished by linking the protein to an insoluble but injectable polymer via a light cleaved linker. This allows the injected material to remain at the site of injection, until transcutaneous irradiation breaks the link between polymer and protein, permitting the protein to be absorbed. However, there are multiple problems associated with polymer based approaches: The polymer makes up a majority of the material, making it inefficient. In addition, after protein release, the polymer has to be cleared from the body, a significant design challenge. In this w

SUBMITTER: Nadendla K 

PROVIDER: S-EPMC6362458 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature