Ontology highlight
ABSTRACT:
SUBMITTER: Larosa M
PROVIDER: S-EPMC6362534 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Experimental biology and medicine (Maywood, N.J.) 20190121 1
<h4>Impact statement</h4>Our article is focused on emerging pathogenetic pathways in systemic lupus erythematosus (SLE). Notably, IL-12 and IL-23 have been described as emerging cytokines in SLE pathogenesis. We know that IL-23 stimulates Th17 cells to produce IL-17. We try to point out the importance of IL-23/Th17 axis in SLE and to focus on the interaction between this axis and IL-12. Ustekinumab, a fully human IgG1κ monoclonal antibody directed towards the p40 shared subunit of IL-12 and IL-2 ...[more]