Two distinct cellular pathways leading to endothelial cell cytotoxicity by silica nanoparticle size.

ABSTRACT:

Background

Silica nanoparticles (SiNPs) are widely used for biosensing and diagnostics, and for the targeted delivery of therapeutic agents. Safety concerns about the biomedical and clinical applications of SiNPs have been raised, necessitating analysis of the effects of their intrinsic properties, such as sizes, shapes, and surface physicochemical characteristics, on human health to minimize risk in biomedical applications. In particular, SiNP size-associated toxicological effects, and the underlying molecular mechanisms in the vascular endothelium remain unclear. This study aimed to elucidate the detailed mechanisms underlying the cellular response to exposure to trace amounts of SiNPs and to determine applicable size criteria for biomedical application.

Methods

To clarify

SUBMITTER: Lee K 

PROVIDER: S-EPMC6362579 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature