Frailty and Changes in Cognitive Function after Kidney Transplantation.

ABSTRACT: BACKGROUND:Restoration of kidney function after kidney transplant generally improves cognitive function. It is unclear whether frail recipients, with higher susceptibility to surgical stressors, achieve such post-transplant cognitive improvements or whether they experience subsequent cognitive decline as they age with a functioning graft. METHODS:In this two-center cohort study, we assessed pretransplant frailty (Fried physical frailty phenotype) and cognitive function (Modified Mini-Mental State Examination) in adult kidney transplant recipients. To investigate potential short- and medium-term effects of frailty on post-transplant cognitive trajectories, we measured cognitive function up to 4 years post-transplant. Using an adjusted mixed effects model with a random slope (time) and inter

SUBMITTER: Chu NM 

PROVIDER: S-EPMC6362628 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature