Melanoma risk prediction using a multilocus genetic risk score in the Women's Health Initiative cohort.

ABSTRACT:

Background

Single-nucleotide polymorphisms (SNPs) associated with melanoma have been identified though genome-wide association studies. However, the combined impact of these SNPs on melanoma development remains unclear, particularly in postmenopausal women who carry a lower melanoma risk.

Objective

We examine the contribution of a combined polygenic risk score on melanoma development in postmenopausal women.

Methods

Genetic risk scores were calculated using 21 genome-wide association study-significant SNPs. Their combined effect on melanoma development was evaluated in 19,102 postmenopausal white women in the clinical trial and observational study arms of the Women's Health Initiative dataset.

Results

Compared to the tertile of weighted genetic risk score with

SUBMITTER: Cho HG 

PROVIDER: S-EPMC6362983 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature