Handling Missing Dosing History in Population Pharmacokinetic Modeling: An Extension to MDM Method.

ABSTRACT: A major challenge in population pharmacokinetic modeling is handling data with missing or potentially incorrect dosing records. Leaving such records untreated or "commented out" will cause bias in parameter estimates. Several approaches were previously developed to address this challenge. Published in 2004, the missing dose method (MDM) demonstrated its robustness in handling missing dosing history in pharmacokinetic (PK) modeling. In this study, we presented two new extensions: a modified MDM method (MDM2) and a compartment initialization method (CIM). Their performance was examined with a large batch of simulated PK studies. For each method, 8,000 models were run, including different model structures, dosing routes, and missing dosing record scenarios. Both MDM2 and CIM exhibited robust

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6363138 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature