Trazodone use and risk of dementia: A population-based cohort study.

ABSTRACT:

Background

In vitro and animal studies have suggested that trazodone, a licensed antidepressant, may protect against dementia. However, no studies have been conducted to assess the effect of trazodone on dementia in humans. This electronic health records study assessed the association between trazodone use and the risk of developing dementia in clinical practice.

Methods and findings

The Health Improvement Network (THIN), an archive of anonymised medical and prescribing records from primary care practices in the United Kingdom, contains records of over 15 million patients. We assessed patients from THIN aged ≥50 years who received at least two consecutive prescriptions for an antidepressant between January 2000 and January 2017. We compared the risk of dementia among patient

SUBMITTER: Brauer R 

PROVIDER: S-EPMC6363148 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature