Comparative effectiveness of H7N9 vaccines in healthy individuals.

ABSTRACT:

Background

Avian H7N9 influenza viruses possess a potential pandemic threat to public health worldwide, and have caused severe infection and high mortality in humans. A series of clinical trials of H7N9 vaccines have been completed. Meta-analyses need to be performed to assess the immunogenicity and safety of H7N9 vaccines.

Methods

Database research with defined selection criteria was conducted in PubMed, Cochrane Central Register of Controlled Trials, the World Health Organization's International Clinical Trials Registry Platform, ClinicalTrials.gov, etc. Data from randomized clinical trials regarding the immunogenicity and safety of H7N9 vaccines were collected and meta-analyzed.

Results

For non-adjuvanted H7N9 vaccines, high dose formulations induced limited immuno

SUBMITTER: Zheng D 

PROVIDER: S-EPMC6363152 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature