Ask1 and Akt act synergistically to promote ROS-dependent regeneration in Drosophila.

ABSTRACT: How cells communicate to initiate a regenerative response after damage has captivated scientists during the last few decades. It is known that one of the main signals emanating from injured cells is the Reactive Oxygen Species (ROS), which propagate to the surrounding tissue to trigger the replacement of the missing cells. However, the link between ROS production and the activation of regenerative signaling pathways is not yet fully understood. We describe here the non-autonomous ROS sensing mechanism by which living cells launch their regenerative program. To this aim, we used Drosophila imaginal discs as a model system due to its well-characterized regenerative ability after injury or cell death. We genetically-induced cell death and found that the Apoptosis signal-regulating kinase 1 (A

SUBMITTER: Santabarbara-Ruiz P 

PROVIDER: S-EPMC6363233 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature